TDRD9

Across TCGA patient cohorts, TDRD9 mutation is significantly associated with the RNA expression of many other genes, with 2,951 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDRD9-associated genes across cancer lineages are ADAM2, CRYBB2P1, and HIRA. Each is linked with TDRD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRD9-to-partner and partner-to-TDRD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by TDRD9-low versus TDRD9-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD9→partner) and Y-score (partner→TDRD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	ADAM2 →	+0.014	+4.039	<.001	.009	3	2
UCEC	CRYBB2P1 →	+0.357	+1.658	.002	.001	3	2
UCEC	HIRA →	+0.342	+1.879	.002	<.001	3	2
UCEC	PACSIN2 →	+0.421	+1.432	<.001	.005	3	2
UCEC	GNPNAT1 →	+0.454	+1.617	.004	.002	3	2
UCEC	VTI1B →	+0.357	+1.857	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,951 associations by consensus.

ADAM2 by TDRD9 expression — SCLC

Explore this box plot interactively →