TDRD6

Across TCGA patient cohorts, TDRD6 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDRD6-associated genes across cancer lineages are ASNS, Cyclin-B1, and p62 Lck ligand. Each is linked with TDRD6 in more than 3 cancer types. Because this analysis shows association rather than direction, both TDRD6-to-partner and partner-to-TDRD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TDRD6-low versus TDRD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD6→partner) and Y-score (partner→TDRD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.296	+1.432	.001	.004	3	4
STAD	Cyclin-B1 →	+0.443	+2.115	.015	.017	2	4
UCEC	p62 Lck ligand →	+0.245	+1.459	.002	.009	3	3
UCEC	PDCD4 →	-0.282	-0.917	.018	.025	3	3
UCEC	ATM →	-0.381	-1.986	<.001	.002	3	3
UCEC	Chk2_pT68 →	-0.140	-1.797	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ASNS by TDRD6 expression — UCEC

Explore this box plot interactively →