TDRD6

Across TCGA cell cohorts, TDRD6 mutation is significantly associated with the RNA expression of many other genes, with 695 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDRD6-associated genes across cancer lineages are TNFAIP3, CARD6, and KLHL3. Each is linked with TDRD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRD6-to-partner and partner-to-TDRD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNFAIP3 grouped by TDRD6-low versus TDRD6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD6→partner) and Y-score (partner→TDRD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNFAIP3 →	-1.072	-2.777	.004	<.001	3	2
LARGE_INTESTINE	CARD6 →	-0.607	-3.087	.006	.007	3	2
LARGE_INTESTINE	KLHL3 →	-0.677	-3.517	.005	<.001	3	2
LARGE_INTESTINE	PLCL2 →	+0.847	+2.482	<.001	.003	3	2
LARGE_INTESTINE	CFAP36 →	+0.595	+3.036	.001	<.001	3	2
LARGE_INTESTINE	C11orf65 →	+0.317	+2.459	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 695 associations by consensus.

TNFAIP3 by TDRD6 expression — LARGE_INTESTINE

Explore this box plot interactively →