TDRD5

Across TCGA patient cohorts, TDRD5 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDRD5-associated genes across cancer lineages are Caspase-7-cleavedD198, p70-S6K_pT389, and FoxM1. Each is linked with TDRD5 in more than 4 cancer types. Because this analysis shows association rather than direction, both TDRD5-to-partner and partner-to-TDRD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TDRD5-low versus TDRD5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD5→partner) and Y-score (partner→TDRD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.000	+2.815	.021	.036	1	5
LUSC	p70-S6K_pT389 →	-0.133	-2.691	.036	.006	3	3
UCEC	FoxM1 →	+0.166	+1.495	.041	.034	3	3
UCEC	TFRC →	+0.488	+3.584	.003	.002	3	3
UCEC	ATM →	-0.540	-2.893	<.001	.001	3	3
UCEC	Di-Ras3 →	-0.125	-1.584	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Caspase-7-cleavedD198 by TDRD5 expression — COAD

Explore this box plot interactively →