TDRD3

Across TCGA pan-cancer cohorts, TDRD3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TDRD3 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TDRD3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TDRD3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where TDRD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.368	0.192	.002	24	view →
CCRCC	DFS	Median	III,IV	0.785	0.406	.003	23	view →
HNSC	DFS	Quartile	All	0.697	0.872	.020	5	view →
LUAD	OS	Median	All	0.939	0.670	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TDRD3–PDAC (DFS)

Open the PDAC breakdown →