TDRD3

Across TCGA patient cohorts, TDRD3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDRD3-associated genes across cancer lineages are EGFR_pY1068, PCNA, and Shc_pY317. Each is linked with TDRD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRD3-to-partner and partner-to-TDRD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TDRD3-low versus TDRD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD3→partner) and Y-score (partner→TDRD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.268	-2.584	<.001	<.001	3	2
UCEC	PCNA →	+0.234	+2.247	<.001	.001	3	2
UCEC	Shc_pY317 →	-0.156	-1.523	.001	.008	3	2
COAD	ASNS →	+0.483	+1.882	.003	.031	3	2
UCEC	Chk2_pT68 →	-0.164	-3.781	.005	<.001	3	2
UCEC	eIF4E →	+0.168	+2.415	.012	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by TDRD3 expression — UCEC

Explore this box plot interactively →