TDRD3

Across TCGA cell cohorts, TDRD3 mutation is significantly associated with the drug of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDRD3-associated genes across cancer lineages are Tivozanib, GSK2276186C, and 630600. Each is linked with TDRD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRD3-to-partner and partner-to-TDRD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tivozanib grouped by TDRD3-low versus TDRD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD3→partner) and Y-score (partner→TDRD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Tivozanib →	+0.258	+3.008	.015	.016	3	2
LARGE_INTESTINE	GSK2276186C →	+0.473	+2.871	.031	.021	3	1
LARGE_INTESTINE	630600 →	+0.697	+2.871	.017	.021	3	1
LARGE_INTESTINE	kb NB 142-70 →	+0.498	+2.874	.026	.021	3	1
LARGE_INTESTINE	Romidepsin →	+0.527	+2.871	.013	.021	2	1
LARGE_INTESTINE	150412 →	+0.391	+3.000	.013	.017	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Tivozanib by TDRD3 expression — LARGE_INTESTINE

Explore this box plot interactively →