Across TCGA cell cohorts, TDRD15 mutation is significantly associated with the RNA expression of many other genes, with 457 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDRD15-associated genes across cancer lineages are PAICS, CARD17, and PRSS55. Each is linked with TDRD15 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRD15-to-partner and partner-to-TDRD15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD15→partner) and Y-score (partner→TDRD15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PAICS →	+0.718	+3.321	<.001	.004	3	2
LUNG_SCLC	CARD17 →	+0.118	+2.777	<.001	.001	3	2
STOMACH	PRSS55 →	+0.072	+3.632	<.001	.009	3	2
LARGE_INTESTINE	NRP2 →	-1.907	-3.541	<.001	.001	3	2
LARGE_INTESTINE	GRSF1 →	+0.454	+2.502	.004	.005	3	2
LARGE_INTESTINE	SSB →	+0.445	+3.321	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 457 associations by consensus.

Exploration

TDRD15 survival (RNA) · tumor vs normal (RNA) · all TDRD15 data types