TDRD12

Across TCGA cell cohorts, TDRD12 mutation is significantly associated with the RNA expression of many other genes, with 595 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDRD12-associated genes across cancer lineages are DAZ2, OR2L5, and TRIML1. Each is linked with TDRD12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRD12-to-partner and partner-to-TDRD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ2 grouped by TDRD12-low versus TDRD12-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD12→partner) and Y-score (partner→TDRD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DAZ2 →	+0.019	+4.643	<.001	.005	3	2
CNS	OR2L5 →	+0.046	+2.730	<.001	.008	3	2
CNS	TRIML1 →	+0.108	+2.824	.001	.005	3	2
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	DEFB108B →	+0.194	+4.736	<.001	.009	3	1
LUNG_SCLC	FASLG →	+0.099	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 595 associations by consensus.

DAZ2 by TDRD12 expression — BLOOD_Lymphoma

Explore this box plot interactively →