TDRD10

Across TCGA cell cohorts, TDRD10 RNA expression is significantly associated with the go_rna of many other GO terms, with 335 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible TDRD10-associated GO terms across cancer lineages are Spliceosomal conformational changes to generate catalytic conformation, Positive regulation of cytoplasmic translation, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with TDRD10 in more than 5 cancer types. Because this analysis shows association rather than direction, both TDRD10-to-partner and partner-to-TDRD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal conformational changes to generate catalytic conformation grouped by TDRD10-low versus TDRD10-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD10→partner) and Y-score (partner→TDRD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Spliceosomal conformational changes to generate catalytic conformation →	+0.061	+0.468	<.001	.008	3	6
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cytoplasmic translation →	+0.095	+0.115	.001	.001	2	5
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.174	+0.741	<.001	.005	2	5
OESOPHAGUS	Cellular respiration →	+0.098	+0.463	<.001	.003	3	4
OESOPHAGUS	Aerobic respiration →	+0.108	+0.558	<.001	.007	3	4
LUNG_NSCLC_LUAD	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.043	+0.423	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 335 associations by consensus.

Spliceosomal conformational changes to generate catalytic conformation by TDRD10 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →