TDRD10

Across TCGA cell cohorts, TDRD10 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDRD10-associated genes across cancer lineages are ASPN, C6orf118, and DEFA4. Each is linked with TDRD10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRD10-to-partner and partner-to-TDRD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPN grouped by TDRD10-low versus TDRD10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD10→partner) and Y-score (partner→TDRD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.043	+3.378	<.001	.006	3	1
LARGE_INTESTINE	C6orf118 →	+0.146	+3.115	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR4F4 →	+0.015	+3.103	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ASPN by TDRD10 expression — LARGE_INTESTINE

Explore this box plot interactively →