TDRD1

Across TCGA pan-cancer cohorts, TDRD1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TDRD1 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher TDRD1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TDRD1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCS, UCEC, and LIHC are the cancer types where TDRD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	All	0.001	0.690	<.001	36	view →
UCEC	DFS	Median	All	0.790	0.624	.001	36	view →
LIHC	OS	Median	III,IV	0.240	0.658	.006	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
SKCM	DFS	Median	II,III,IV	0.901	0.672	.004	8	view →
SARC	DFS	Median	All	0.094	0.591	.004	6	view →
COAD	DFS	Median	II,III,IV	0.200	0.648	.019	6	view →
PRAD	DFS	Median	All	0.617	0.886	.011	6	view →
STAD	OS	Median	III,IV	0.113	0.642	<.001	6	view →
LUSC	OS	Median	All	0.196	0.724	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TDRD1–UCS (OS)

Open the UCS breakdown →