TDRD1

Across TCGA patient cohorts, TDRD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,685 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible TDRD1-associated GO terms across cancer lineages are Ribosome-associated ubiquitin-dependent protein catabolic process, Positive regulation of mRNA metabolic process, and Polyadenylation-dependent RNA catabolic process. Each is linked with TDRD1 in more than 11 cancer types. Because this analysis shows association rather than direction, both TDRD1-to-partner and partner-to-TDRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosome-associated ubiquitin-dependent protein catabolic process grouped by TDRD1-low versus TDRD1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD1→partner) and Y-score (partner→TDRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Ribosome-associated ubiquitin-dependent protein catabolic process →	+0.094	+0.297	<.001	.003	3	12
STAD	Positive regulation of mRNA metabolic process →	+0.101	+0.358	<.001	<.001	2	11
STAD	Polyadenylation-dependent RNA catabolic process →	+0.065	+0.318	<.001	.002	2	11
STAD	Transcription by RNA polymerase I →	+0.063	+0.322	<.001	<.001	3	10
ESCA	Protein deglycosylation →	+0.090	+0.434	<.001	<.001	1	12
STAD	Mitochondrial transport →	+0.106	+0.375	<.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,685 associations by consensus.

Ribosome-associated ubiquitin-dependent protein catabolic process by TDRD1 expression — STAD

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