TDRD1

Across TCGA cell cohorts, TDRD1 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible TDRD1-associated genes across cancer lineages are TGIF2LX, VGLL2, and NCBP2L. Each is linked with TDRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRD1-to-partner and partner-to-TDRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGIF2LX grouped by TDRD1-low versus TDRD1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD1→partner) and Y-score (partner→TDRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TGIF2LX →	+0.053	+5.000	<.001	.005	3	2
BLOOD_Lymphoma	VGLL2 →	+0.770	+4.321	<.001	.002	3	2
BLOOD_Lymphoma	NCBP2L →	+0.017	+4.058	<.001	.009	3	2
OESOPHAGUS	NAT8B →	+0.036	+4.017	<.001	.007	3	1
BLOOD_Myeloma	FHL5 →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	MBL2 →	+0.016	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

TGIF2LX by TDRD1 expression — KIDNEY

Explore this box plot interactively →