TDP1

Across TCGA cell cohorts, TDP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,996 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TDP1-associated GO terms across cancer lineages are DNA replication, Interstrand cross-link repair, and Regulation of chromosome separation. Each is linked with TDP1 in more than 16 cancer types. Because this analysis shows association rather than direction, both TDP1-to-partner and partner-to-TDP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by TDP1-low versus TDP1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TDP1→partner) and Y-score (partner→TDP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.109	+1.349	.004	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Interstrand cross-link repair →	+0.086	+1.271	<.001	<.001	3	16
KIDNEY	Regulation of chromosome separation →	+0.182	+1.246	<.001	<.001	3	16
KIDNEY	Regulation of metaphase/anaphase transition of cell cycle →	+0.139	+1.162	<.001	<.001	3	15
KIDNEY	Microtubule cytoskeleton organization involved in mitosis →	+0.100	+1.213	<.001	<.001	3	15
KIDNEY	Regulation of mitotic metaphase/anaphase transition →	+0.143	+1.162	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,996 associations by consensus.

DNA replication by TDP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →