TDP1

Across TCGA cell cohorts, TDP1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDP1-associated genes across cancer lineages are ASB17, SCGB2A1, and SPATA4. Each is linked with TDP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDP1-to-partner and partner-to-TDP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by TDP1-low versus TDP1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDP1→partner) and Y-score (partner→TDP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
LARGE_INTESTINE	SCGB2A1 →	+0.579	+3.392	<.001	.006	3	1
LARGE_INTESTINE	SPATA4 →	+0.143	+3.432	.003	.006	3	1
LARGE_INTESTINE	CPLX4 →	+0.020	+3.807	.003	.001	3	1
LARGE_INTESTINE	VWC2L →	+0.008	+3.345	<.001	.001	3	1
LARGE_INTESTINE	DBX2 →	+0.009	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ASB17 by TDP1 expression — OVARY

Explore this box plot interactively →