TDO2

Across TCGA patient cohorts, TDO2 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,512 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TDO2-associated proteins across cancer lineages are STK10, PPP1R18_S224, and WAS. Each is linked with TDO2 in more than 8 cancer types. Because this analysis shows association rather than direction, both TDO2-to-partner and partner-to-TDO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TDO2 versus STK10 in UCEC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TDO2→partner) and Y-score (partner→TDO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STK10 →	+0.402	+0.725	<.001	.001	3	9
LSCC	PPP1R18_S224 →	+0.647	+0.955	<.001	<.001	3	9
GBM	WAS →	+0.531	+1.356	<.001	<.001	3	8
GBM	CD163 →	+0.727	+1.060	<.001	<.001	3	8
BRCA	DOCK2 →	+0.536	+1.175	<.001	<.001	3	8
GBM	HCK →	+0.637	+1.158	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,512 associations by consensus.

TDO2 vs STK10 — UCEC

Explore this scatter interactively →