TDO2

Across TCGA patient cohorts, TDO2 protein abundance is significantly associated with the protein abundance of many other proteins, with 479 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TDO2-associated proteins across cancer lineages are CHMP4A, PBRM1, and PHF3_S125. Each is linked with TDO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDO2-to-partner and partner-to-TDO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TDO2 versus CHMP4A in LSCC, with a Pearson correlation of 0.74.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TDO2→partner) and Y-score (partner→TDO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CHMP4A →	+0.493	+1.890	.003	.009	2	1
LSCC	PBRM1 →	-0.675	-1.741	.007	.007	1	2
LSCC	PHF3_S125 →	-0.919	-1.773	.007	.003	2	1
GBM	SKAP2 →	+1.701	+1.548	<.001	.007	1	2
LSCC	SLC38A10_S997 →	+0.910	+1.990	<.001	.005	2	1
LSCC	SSH1 →	+0.436	+1.990	.009	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 479 associations by consensus.

TDO2 vs CHMP4A — LSCC

Explore this scatter interactively →