TDO2

Across TCGA patient cohorts, TDO2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDO2-associated genes across cancer lineages are FoxM1, TFRC, and MEK1. Each is linked with TDO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TDO2-to-partner and partner-to-TDO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TDO2-low versus TDO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDO2→partner) and Y-score (partner→TDO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.369	+2.115	.001	.019	3	3
UCEC	TFRC →	+0.704	+2.999	.002	.035	3	3
UCEC	MEK1 →	+0.583	+3.700	<.001	.001	3	2
UCEC	eIF4G →	+0.343	+2.115	.011	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.148	-2.575	.006	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.224	-3.584	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

FoxM1 by TDO2 expression — UCEC

Explore this box plot interactively →