TDO2

Across TCGA cell cohorts, TDO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,218 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TDO2-associated GO terms across cancer lineages are Protein folding, UDP-N-acetylglucosamine biosynthetic process, and Cotranslational protein targeting to membrane. Each is linked with TDO2 in more than 8 cancer types. Because this analysis shows association rather than direction, both TDO2-to-partner and partner-to-TDO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein folding grouped by TDO2-low versus TDO2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TDO2→partner) and Y-score (partner→TDO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Protein folding →	+0.052	+0.833	.003	.008	3	9
LUNG_NSCLC_LUAD	UDP-N-acetylglucosamine biosynthetic process →	+0.067	+1.119	.007	.004	3	7
BLOOD_Lymphoma	Cotranslational protein targeting to membrane →	+0.060	+0.553	.002	.003	3	7
CNS	Vesicle cargo loading →	+0.081	+1.450	.001	.004	3	6
LUNG_SCLC	Indole-containing compound catabolic process →	-0.307	-1.180	<.001	<.001	3	6
STOMACH	Response to folic acid →	-0.177	-0.902	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,218 associations by consensus.

Protein folding by TDO2 expression — URINARY_TRACT

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