TDO2

Across TCGA cell cohorts, TDO2 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDO2-associated genes across cancer lineages are KRTAP1-1, TGM7, and OR13C2. Each is linked with TDO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDO2-to-partner and partner-to-TDO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP1-1 grouped by TDO2-low versus TDO2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDO2→partner) and Y-score (partner→TDO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP1-1 →	+0.068	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	TGM7 →	+0.006	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR13C2 →	+0.015	+4.887	<.001	.009	3	1
LARGE_INTESTINE	ASPN →	+0.057	+3.841	<.001	<.001	3	1
LARGE_INTESTINE	SLC30A9 →	+0.773	+3.082	<.001	.007	3	1
LARGE_INTESTINE	MAD2L1 →	+1.003	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

KRTAP1-1 by TDO2 expression — BLOOD_Lymphoma

Explore this box plot interactively →