Across TCGA pan-cancer cohorts, TDGF1P4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of TDGF1P4’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TDGF1P4 RNA is repressed in tumor relative to normal tissue. In most cancer types TDGF1P4 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC and PRAD are the cancer types where TDGF1P4 tumor–normal differential expression is most reproducible.