TDGF1

Across TCGA patient cohorts, TDGF1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDGF1-associated genes across cancer lineages are 14-3-3_beta, Ku80, and MEK1. Each is linked with TDGF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDGF1-to-partner and partner-to-TDGF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TDGF1-low versus TDGF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDGF1→partner) and Y-score (partner→TDGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.149	-2.794	<.001	.003	3	1
UCEC	Ku80 →	+0.259	+2.128	.012	.010	3	1
UCEC	MEK1 →	+0.503	+3.700	.001	.001	3	1
UCEC	Notch1 →	+0.195	+3.013	.001	.018	3	1
UCEC	N-Ras →	-0.133	-3.302	.010	.010	3	1
UCEC	14-3-3_epsilon →	-0.105	-2.115	.015	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

14-3-3_beta by TDGF1 expression — UCEC

Explore this box plot interactively →