TDGF1

Across TCGA cell cohorts, TDGF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,468 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDGF1-associated GO terms across cancer lineages are Negative regulation of T cell mediated cytotoxicity, Serotonin metabolic process, and Brush border assembly. Each is linked with TDGF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TDGF1-to-partner and partner-to-TDGF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of T cell mediated cytotoxicity grouped by TDGF1-low versus TDGF1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TDGF1→partner) and Y-score (partner→TDGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of T cell mediated cytotoxicity →	+1.400	+1.512	<.001	.009	3	5
LARGE_INTESTINE	Serotonin metabolic process →	+0.208	+2.157	<.001	<.001	3	4
LARGE_INTESTINE	Brush border assembly →	+0.713	+1.886	.002	.002	3	4
LARGE_INTESTINE	Phosphate ion transmembrane transport →	+0.140	+2.244	<.001	.001	3	4
LARGE_INTESTINE	Indole-containing compound metabolic process →	+0.138	+2.075	<.001	<.001	3	4
LARGE_INTESTINE	Trigeminal ganglion development →	-0.737	-2.046	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,468 associations by consensus.

Negative regulation of T cell mediated cytotoxicity by TDGF1 expression — STOMACH

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