TCTN3

Across TCGA patient cohorts, TCTN3 mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCTN3-associated genes across cancer lineages are pDC, Th2 cells, and CD8+ Tcm. Each is linked with TCTN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCTN3-to-partner and partner-to-TCTN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, pDC grouped by TCTN3-low versus TCTN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCTN3→partner) and Y-score (partner→TCTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	pDC →	+0.065	+3.032	.004	.018	3	2
UCEC	Th2 cells →	+0.276	+3.180	.001	.010	3	2
LUSC	CD8+ Tcm →	+0.067	+3.729	.001	.021	3	1
SKCM	Pericytes →	+0.071	+3.591	.015	.009	3	1
UCEC	Erythrocytes →	+0.031	+2.818	.007	.035	3	1
UCEC	mv Endothelial cells →	-0.026	-3.000	.018	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

pDC by TCTN3 expression — UCEC

Explore this box plot interactively →