TCTN2

Across TCGA patient cohorts, TCTN2 mutation is significantly associated with the RNA expression of many other genes, with 1,039 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCTN2-associated genes across cancer lineages are UBE2V1P8, OR4H12P, and RNU6-295P. Each is linked with TCTN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TCTN2-to-partner and partner-to-TCTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2V1P8 grouped by TCTN2-low versus TCTN2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCTN2→partner) and Y-score (partner→TCTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UBE2V1P8 →	+0.095	+4.986	<.001	.003	3	3
THCA	OR4H12P →	+0.029	+7.962	<.001	.007	3	2
THCA	RNU6-295P →	+0.388	+7.962	<.001	.007	3	2
UCEC	SKA1 →	+0.589	+2.332	.002	<.001	3	2
UCEC	TRIM17 →	-1.049	-1.915	<.001	.005	3	2
UCEC	CHAF1A →	+0.585	+2.343	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,039 associations by consensus.

UBE2V1P8 by TCTN2 expression — BRCA

Explore this box plot interactively →