TCTN2

Across TCGA patient cohorts, TCTN2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCTN2-associated genes across cancer lineages are Tuberin_pT1462, 4E-BP1, and Cyclin-B1. Each is linked with TCTN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCTN2-to-partner and partner-to-TCTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by TCTN2-low versus TCTN2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCTN2→partner) and Y-score (partner→TCTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Tuberin_pT1462 →	-0.211	-2.990	.049	.036	3	2
SKCM	4E-BP1 →	+0.498	+3.169	.002	.019	3	2
SKCM	Cyclin-B1 →	+0.710	+2.820	.001	.035	3	2
UCEC	FoxM1 →	+0.195	+1.765	.045	.014	3	2
UCEC	Ku80 →	+0.233	+2.472	.008	.010	3	2
UCEC	MEK1 →	+0.322	+2.222	.019	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Tuberin_pT1462 by TCTN2 expression — LUSC

Explore this box plot interactively →