Across TCGA pan-cancer cohorts, TCTN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TCTN1 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TCTN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TCTN1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where TCTN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.599	0.954	.004	34	view →
UCEC	OS	Tertile	III,IV	0.252	1.000	.016	14	view →
CCRCC	DFS	Tertile	III,IV	0.400	0.974	.012	12	view →
PDAC	OS	Median	All	0.123	1.000	.038	6	view →
LUAD	DFS	Quartile	II,III,IV	0.753	0.465	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TCTN1 tumor-vs-normal RNA expression · all TCTN1 data types