TCTN1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TCTN1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCTN1-associated genes across cancer lineages are ERK2, GAPDH, and MEK1. Each is linked with TCTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCTN1-to-partner and partner-to-TCTN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCTN1→partner) and Y-score (partner→TCTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECERK2 →+0.157+2.459.018.01832
UCECGAPDH →+0.395+1.807.034.02432
UCECMEK1 →+0.413+3.087.001<.00132
UCECNF2 →+0.200+2.459.007.01832
UCECPR →-0.200-2.222.021.01032
UCECTFRC →+0.376+1.700.041.04232
Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

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