TCTE1

Across TCGA patient cohorts, TCTE1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCTE1-associated genes across cancer lineages are eIF4E, ERK2, and INPP4B. Each is linked with TCTE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCTE1-to-partner and partner-to-TCTE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TCTE1-low versus TCTE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCTE1→partner) and Y-score (partner→TCTE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.177	+1.874	.012	.002	3	2
UCEC	ERK2 →	+0.174	+1.321	.006	.029	3	2
UCEC	INPP4B →	-0.240	-2.000	.027	.029	3	2
UCEC	MEK1 →	+0.475	+2.201	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.140	-1.584	.004	.009	3	2
UCEC	Notch1 →	+0.137	+2.331	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

eIF4E by TCTE1 expression — UCEC

Explore this box plot interactively →