TCTA

Across TCGA cell cohorts, TCTA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,132 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TCTA-associated GO terms across cancer lineages are Osteoclast fusion, GDP-mannose biosynthetic process, and Methylglyoxal metabolic process. Each is linked with TCTA in more than 11 cancer types. Because this analysis shows association rather than direction, both TCTA-to-partner and partner-to-TCTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Osteoclast fusion grouped by TCTA-low versus TCTA-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TCTA→partner) and Y-score (partner→TCTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Osteoclast fusion →	+0.225	+1.163	<.001	<.001	3	12
STOMACH	GDP-mannose biosynthetic process →	+0.138	+0.896	.009	.006	2	12
URINARY_TRACT	Methylglyoxal metabolic process →	+0.171	+0.894	<.001	.002	3	10
KIDNEY	Positive regulation of TORC2 signaling →	+0.106	+1.199	<.001	<.001	3	10
SKIN	Vacuole organization →	+0.058	+1.236	<.001	<.001	3	9
SOFT_TISSUE	Multinuclear osteoclast differentiation →	+0.193	+0.900	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,132 associations by consensus.

Osteoclast fusion by TCTA expression — SOFT_TISSUE

Explore this box plot interactively →