TCP11L1

Across TCGA pan-cancer cohorts, TCP11L1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TCP11L1 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TCP11L1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TCP11L1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where TCP11L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.649	0.928	.001	29	view →
HNSC	DFS	Quartile	III,IV	0.914	0.630	.007	14	view →
LUAD	DFS	Median	II,III,IV	0.914	0.755	.021	7	view →
PDAC	DFS	Quartile	II,III,IV	0.498	0.279	.012	4	view →
LSCC	OS	Tertile	All	0.628	0.991	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TCP11L1–CCRCC (DFS)

Open the CCRCC breakdown →