TCP11L1

Across TCGA patient cohorts, TCP11L1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCP11L1-associated genes across cancer lineages are eIF4E, ERK2, and FoxM1. Each is linked with TCP11L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCP11L1-to-partner and partner-to-TCP11L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TCP11L1-low versus TCP11L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP11L1→partner) and Y-score (partner→TCP11L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.180	+1.906	.033	.016	3	1
UCEC	ERK2 →	+0.175	+2.000	.024	.030	3	1
UCEC	FoxM1 →	+0.205	+2.415	.049	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.136	-2.321	.045	.034	3	1
UCEC	MEK1 →	+0.460	+3.087	.001	<.001	3	1
UCEC	mTOR_pS2448 →	-0.135	-2.986	.024	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eIF4E by TCP11L1 expression — UCEC

Explore this box plot interactively →