TCP11L1

Across TCGA cell cohorts, TCP11L1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCP11L1-associated genes across cancer lineages are SPATA31A7, PRSS54, and ADGRE3. Each is linked with TCP11L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCP11L1-to-partner and partner-to-TCP11L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31A7 grouped by TCP11L1-low versus TCP11L1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP11L1→partner) and Y-score (partner→TCP11L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SPATA31A7 →	+0.043	+5.000	<.001	.005	3	2
KIDNEY	PRSS54 →	+0.036	+5.000	<.001	.005	3	1
KIDNEY	ADGRE3 →	+0.040	+5.000	<.001	.005	3	1
KIDNEY	PRR32 →	+0.013	+5.000	<.001	.005	3	1
KIDNEY	LCE1F →	+0.226	+5.000	<.001	.005	3	1
KIDNEY	ZNF723 →	+0.006	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

SPATA31A7 by TCP11L1 expression — KIDNEY

Explore this box plot interactively →