TCP11

Across TCGA patient cohorts, TCP11 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCP11-associated genes across cancer lineages are MEK1, mTOR_pS2448, and N-Cadherin. Each is linked with TCP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCP11-to-partner and partner-to-TCP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TCP11-low versus TCP11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP11→partner) and Y-score (partner→TCP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.297	+2.000	.034	.030	3	2
UCEC	mTOR_pS2448 →	-0.173	-2.571	.002	.010	3	2
UCEC	N-Cadherin →	+0.217	+2.321	.007	.033	3	2
UCEC	p27_pT198 →	+0.119	+3.169	.003	.018	3	2
UCEC	p38-MAPK →	-0.159	-1.678	.011	.023	3	2
UCEC	Shc_pY317 →	-0.161	-2.087	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MEK1 by TCP11 expression — UCEC

Explore this box plot interactively →