TCP11

Across TCGA cell cohorts, TCP11 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,464 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TCP11-associated GO terms across cancer lineages are Regulation of sperm capacitation, Positive regulation of protein K48-linked ubiquitination, and Peptidyl-lysine oxidation. Each is linked with TCP11 in more than 8 cancer types. Because this analysis shows association rather than direction, both TCP11-to-partner and partner-to-TCP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of sperm capacitation grouped by TCP11-low versus TCP11-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP11→partner) and Y-score (partner→TCP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of sperm capacitation →	+0.253	+0.292	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of protein K48-linked ubiquitination →	+0.115	+0.145	.007	.008	3	7
SKIN	Peptidyl-lysine oxidation →	+1.171	+0.510	<.001	<.001	3	7
BONE	Negative regulation of proteolysis →	+0.150	+0.248	.002	.007	3	6
BONE	Regulation of protein exit from endoplasmic reticulum →	+0.104	+0.207	.001	.001	3	6
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	+0.147	+0.194	<.001	.009	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,464 associations by consensus.

Regulation of sperm capacitation by TCP11 expression — BLOOD_Leukemia

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