TCOF1

Across TCGA pan-cancer cohorts, TCOF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TCOF1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TCOF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TCOF1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where TCOF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.291	0.877	<.001	23	view →
PDAC	OS	Median	II,III,IV	0.437	0.591	.010	5	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
HNSC	OS	Median	IV	0.756	0.900	.030	2	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.865	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TCOF1–CCRCC (OS)

Open the CCRCC breakdown →