TCOF1

Across TCGA cell cohorts, TCOF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,060 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TCOF1-associated GO terms across cancer lineages are DNA replication initiation, Double-strand break repair via break-induced replication, and DNA-templated transcription termination. Each is linked with TCOF1 in more than 19 cancer types. Because this analysis shows association rather than direction, both TCOF1-to-partner and partner-to-TCOF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by TCOF1-low versus TCOF1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TCOF1→partner) and Y-score (partner→TCOF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.189	+1.292	.003	<.001	3	20
OVARY	Double-strand break repair via break-induced replication →	+0.245	+0.990	<.001	<.001	3	19
LIVER	DNA-templated transcription termination →	+0.112	+1.223	.001	<.001	3	19
BONE	Transcription initiation at RNA polymerase I promoter →	+0.122	+0.843	<.001	.006	3	19
OESOPHAGUS	Maturation of SSU-rRNA →	+0.174	+1.421	<.001	<.001	3	19
OESOPHAGUS	Ribosome biogenesis →	+0.128	+1.127	.001	.007	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,060 associations by consensus.

DNA replication initiation by TCOF1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →