Across TCGA patient cohorts, TCN2 mutation is significantly associated with the RNA expression of many other genes, with 609 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCN2-associated genes across cancer lineages are SPR, SNRPCP8, and RPL23AP69. Each is linked with TCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCN2-to-partner and partner-to-TCN2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCN2→partner) and Y-score (partner→TCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPR →	+0.639	+3.198	.006	.009	3	2
SKCM	SNRPCP8 →	+0.151	+2.584	.005	.002	3	2
COAD	RPL23AP69 →	+0.276	+3.224	<.001	.002	3	2
COAD	MIR6854 →	+0.360	+4.335	<.001	.005	3	2
UCEC	CHCHD4 →	+0.413	+3.346	.005	.005	3	2
UCEC	ELP5 →	+0.520	+3.385	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 609 associations by consensus.

Exploration

TCN2 survival (RNA) · tumor vs normal (RNA) · all TCN2 data types