Across TCGA patient cohorts, TCN2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCN2-associated genes across cancer lineages are Notch1, PCNA, and 4E-BP1_pT70. Each is linked with TCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCN2-to-partner and partner-to-TCN2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCN2→partner) and Y-score (partner→TCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.236	+3.183	<.001	.009	3	2
UCEC	PCNA →	+0.283	+2.000	.003	.030	3	2
COAD	4E-BP1_pT70 →	+0.123	+3.008	.047	.019	3	1
UCEC	ER-alpha_pS118 →	+0.350	+2.000	.030	.032	3	1
UCEC	FoxM1 →	+0.317	+2.331	.006	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.129	-2.999	.021	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

TCN2 survival (RNA) · tumor vs normal (RNA) · all TCN2 data types