TCN1

Across TCGA patient cohorts, TCN1 mutation is significantly associated with the RNA expression of many other genes, with 2,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCN1-associated genes across cancer lineages are MIR1915, RNA5SP451, and RNA5SP419. Each is linked with TCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCN1-to-partner and partner-to-TCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1915 grouped by TCN1-low versus TCN1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCN1→partner) and Y-score (partner→TCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR1915 →	+0.532	+2.918	<.001	.002	3	2
LUSC	RNA5SP451 →	+0.090	+4.593	.001	.003	3	2
UCEC	RNA5SP419 →	+0.588	+2.077	<.001	.003	3	2
LUSC	RNA5SP408 →	+0.403	+4.918	<.001	.002	3	2
UCEC	RNA5SP422 →	+0.906	+2.256	<.001	<.001	3	2
LUAD	MIR6894 →	+0.835	+4.037	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,207 associations by consensus.

MIR1915 by TCN1 expression — LUSC

Explore this box plot interactively →