TCN1

Across TCGA patient cohorts, TCN1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCN1-associated genes across cancer lineages are PCNA, C-Raf, and 4E-BP1_pS65. Each is linked with TCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCN1-to-partner and partner-to-TCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TCN1-low versus TCN1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCN1→partner) and Y-score (partner→TCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.266	+3.169	.011	.019	3	2
UCEC	C-Raf →	+0.263	+3.584	<.001	.002	3	2
SKCM	4E-BP1_pS65 →	+0.236	+3.012	.029	.018	3	1
UCEC	EGFR_pY1068 →	-0.314	-2.222	.003	.011	3	1
UCEC	eIF4E →	+0.235	+3.321	.008	.010	2	2
UCEC	FoxM1 →	+0.306	+2.906	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PCNA by TCN1 expression — SKCM

Explore this box plot interactively →