TCN1

Across TCGA cell cohorts, TCN1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCN1-associated genes across cancer lineages are TFDP3, NEXMIF, and CEACAM20. Each is linked with TCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCN1-to-partner and partner-to-TCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by TCN1-low versus TCN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCN1→partner) and Y-score (partner→TCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.283	+3.196	<.001	.007	3	1
LARGE_INTESTINE	CEACAM20 →	+0.192	+3.700	<.001	.008	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TFDP3 by TCN1 expression — LARGE_INTESTINE

Explore this box plot interactively →