Across TCGA patient cohorts, TCL6 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCL6-associated genes across cancer lineages are eIF4E, eIF4G, and FoxM1. Each is linked with TCL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCL6-to-partner and partner-to-TCL6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCL6→partner) and Y-score (partner→TCL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.176	+1.807	.043	.027	3	2
SKCM	eIF4G →	+0.300	+1.678	.047	.022	3	2
UCEC	FoxM1 →	+0.211	+3.000	.048	.001	3	2
UCEC	TFRC →	+0.525	+3.169	.016	.018	3	2
UCEC	4E-BP1 →	+0.262	+2.351	.019	.018	3	2
UCEC	Cyclin-B1 →	+0.759	+3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

TCL6 survival (RNA) · tumor vs normal (RNA) · all TCL6 data types