TCIRG1

Across TCGA patient cohorts, TCIRG1 mutation is significantly associated with the RNA expression of many other genes, with 2,978 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCIRG1-associated genes across cancer lineages are NDUFAF2, ENTR1, and SLC25A33. Each is linked with TCIRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCIRG1-to-partner and partner-to-TCIRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF2 grouped by TCIRG1-low versus TCIRG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCIRG1→partner) and Y-score (partner→TCIRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF2 →	+0.643	+3.608	<.001	.001	3	2
UCEC	ENTR1 →	+0.448	+2.042	.001	.005	3	2
UCEC	SLC25A33 →	+0.558	+2.815	.001	.001	3	2
UCEC	MSANTD3 →	+0.661	+3.180	<.001	<.001	3	2
COAD	IQCF1 →	+0.550	+3.616	<.001	.008	3	2
HNSC	RNU6-719P →	+0.296	+6.948	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,978 associations by consensus.

NDUFAF2 by TCIRG1 expression — UCEC

Explore this box plot interactively →