TCHP

Across TCGA patient cohorts, TCHP mutation is significantly associated with the RNA expression of many other genes, with 2,459 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCHP-associated genes across cancer lineages are RBBP4P3, OR2AL1P, and RN7SL25P. Each is linked with TCHP in more than 1 cancer types. Because this analysis shows association rather than direction, both TCHP-to-partner and partner-to-TCHP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBBP4P3 grouped by TCHP-low versus TCHP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCHP→partner) and Y-score (partner→TCHP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RBBP4P3 →	+0.358	+3.789	<.001	.005	3	2
COAD	OR2AL1P →	+0.171	+5.734	<.001	<.001	3	2
BLCA	RN7SL25P →	+0.239	+3.718	<.001	.001	3	2
BLCA	NUDT19P6 →	+0.071	+4.296	<.001	.006	3	2
BLCA	MIR6766 →	+0.538	+4.603	<.001	<.001	3	2
COAD	OR56A3 →	+0.134	+4.251	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,459 associations by consensus.

RBBP4P3 by TCHP expression — COAD

Explore this box plot interactively →