TCHP

Across TCGA patient cohorts, TCHP mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCHP-associated genes across cancer lineages are eEF2, INPP4B, and MEK1. Each is linked with TCHP in more than 1 cancer types. Because this analysis shows association rather than direction, both TCHP-to-partner and partner-to-TCHP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TCHP-low versus TCHP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCHP→partner) and Y-score (partner→TCHP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.463	+2.700	.004	.006	3	2
UCEC	INPP4B →	-0.327	-2.687	.025	.006	3	2
UCEC	MEK1 →	+0.505	+3.169	.002	.018	3	2
UCEC	NF2 →	+0.363	+3.321	<.001	.009	3	2
UCEC	TFRC →	+0.645	+2.700	.006	.006	3	2
UCEC	EGFR_pY1068 →	-0.400	-3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eEF2 by TCHP expression — UCEC

Explore this box plot interactively →