TCHH

Across TCGA patient cohorts, TCHH mutation is significantly associated with the total protein of many other genes, with 85 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCHH-associated genes across cancer lineages are Cyclin-B1, LKB1, and c-Kit. Each is linked with TCHH in more than 5 cancer types. Because this analysis shows association rather than direction, both TCHH-to-partner and partner-to-TCHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TCHH-low versus TCHH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCHH→partner) and Y-score (partner→TCHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.619	+1.784	<.001	<.001	3	6
STAD	LKB1 →	-0.087	-3.000	.026	.033	3	4
SKCM	c-Kit →	-0.598	-1.906	.022	.016	3	4
SKCM	CD31 →	-0.166	-2.983	.009	.034	3	4
UCEC	PCNA →	+0.164	+1.398	.007	.004	3	4
UCEC	Chk2_pT68 →	-0.147	-2.143	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

Cyclin-B1 by TCHH expression — UCEC

Explore this box plot interactively →