TCHH

Across TCGA cell cohorts, TCHH mutation is significantly associated with the RNA expression of many other genes, with 879 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCHH-associated genes across cancer lineages are DNAL1, IL36A, and TWF2. Each is linked with TCHH in more than 2 cancer types. Because this analysis shows association rather than direction, both TCHH-to-partner and partner-to-TCHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAL1 grouped by TCHH-low versus TCHH-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCHH→partner) and Y-score (partner→TCHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DNAL1 →	+0.431	+3.176	.008	.008	3	3
BLOOD_Leukemia	IL36A →	+0.402	+1.919	.005	.008	3	3
LUNG_SCLC	TWF2 →	+0.673	+3.459	.001	.002	3	3
LARGE_INTESTINE	GTF2A1 →	+0.544	+2.458	<.001	<.001	3	3
BONE	NPVF →	+0.053	+4.672	<.001	.001	3	2
BONE	CD300E →	+0.026	+4.307	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 879 associations by consensus.

DNAL1 by TCHH expression — BLOOD_Leukemia

Explore this box plot interactively →