TCF7L2

Across TCGA patient cohorts, TCF7L2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF7L2-associated genes across cancer lineages are Caspase-7-cleavedD198, Bim, and PDK1. Each is linked with TCF7L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TCF7L2-to-partner and partner-to-TCF7L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TCF7L2-low versus TCF7L2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF7L2→partner) and Y-score (partner→TCF7L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+1.127	+3.000	.001	.034	3	3
COAD	Bim →	-0.256	-3.807	.003	<.001	3	3
UCEC	PDK1 →	+0.080	+2.235	.019	.005	3	3
STAD	PI3K-p85 →	+0.171	+3.169	.039	.019	3	2
COAD	Caveolin-1 →	-0.488	-1.874	.035	.047	3	2
UCEC	MSH6 →	-0.426	-2.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by TCF7L2 expression — STAD

Explore this box plot interactively →